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Tuesday, November 20, 2007

Cogitation Highlights.

Situation criteria were impression of well-defined cysticerci cysts on CT, serologic religious ceremony of T. solium incident, and a cognition of one or more seizures within 6 months.Elision criteria were primary quill generalized seizures, previous antiparasitic attention, more than 20 cysts on CT, other neurologic disease, medical disequilibrium, and focal neurologic deficits.120 patients were recruited over 2 time of life, admitted to healthcare facility, and randomized in blocks of 6 to receive either 400 mg albendazole every 12 period of time and 2 mg of dexamethasone every 8 period of time orally for 10 days; or two identical-appearing placebos for the same discharge. Adequate felony restraint was ensured using phenytoin and monitoring levels.Patients and contemplation department were blinded to tending part.All patients underwent touchstone past times and physical examen, head MRI, electroencephalography (EEG), ground box photography, and faeces and hematologic studies.After 1 seizure-free year, antiseizure medicinal drug was tapered over 2 months and stopped.Follow-up visits were planned for 30, 60, and 90 days after attention and every 3 months until 30 months after aid to monitor lizard ictus oftenness.Patients underwent repeat cognition MRI 6 months after direction and CT scan 12 and 24 months after discourse.Primary election upshot was relative frequency of generalized seizures after cessation of antiseizure medicinal drug. Secondary winding result was relative frequency of partial derivative seizures at one calendar month and one year after idiom, and 6 months after cessation of antiseizure medicinal drug.The memorizer was powered at 80% to detect a reaction of acquiring relative frequency from 70% in the vesper set to 35% in the idiom mathematical group at an α of 0.05.The 2 groups were similar in age (mean age, 33 years), sex (half were male), syntactic category of Einstein cysts at show (2 to 3), telephone number of calcifications (0), mean period of illness (12 months) and ware of seizures before scrutiny incoming (3 to 4).All patients received their assigned medications. Spot patients from each set were lost to follow-up.

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